HPE ProLiant DL380 Gen10 Plus 4310 12c 1P 2x32GB-R SR416i-a 2x480GB SATA SSD 2x800W PS EU Server (P80569-425)

Lifecycle

• Obsolete Date 10-07-2025

Specifications

• Accelerators Optional
• Included memory 64 GB (2×32 GB, 3200 MT/s)
• Included drives 2x HPE 480GB SATA 6G Read Intensive SFF BC Multi Vendor SSD
• Processor cache 18 MB L3
• Processor name Intel® Xeon® Silver 4310 (12 core, 2.10 GHz, 18 MB L3, 120W)
• System fan features 6x Maximum Performance Fans
• Network controller Broadcom BCM5719 Ethernet 1Gb 4-port BASE-T OCP3 Adapter for HPE
• NVDIMM capacity Optional: 128 GB – 512 GB
• NVDIMM type Optional: Intel® Optane™ Persistent Memory for HPE
• Security Optional locking Bezel Kit, Intrusion Detection Kit, and HPE TPM 2.0
• Infrastructure management HPE iLO Standard with intelligent provisioning (embedded), HPE OneView Standard (requires download) (standard) HPE iLO Advanced, and HPE OneView Advanced (optional, requires licenses)
• Storage controller HPE SR416i-a Gen10 Plus x16 Lanes 4GB Cache NVMe/SAS 24G Controller
• Optical drive type Optional DVD-ROM Optional via Universal Media Bay External support only
• Form factor 2U Rack
• Expansion slots 8, for detailed descriptions refer to the QuickSpecs
• Processor core available 12 core
• Processor number 1 processor included
• Processor speed 2.10 GHz
• Warranty 3/3/3: Server Warranty includes three years of parts, three years of labor, and three years of onsite support coverage. Additional information regarding worldwide limited warranty and technical support is available at: https://support.hpe.com/hpesc/public/docDisplay?docId=sd00004309en_us. Additional HPE support and service coverage, to supplement the product warranty, is available. For more information, visit https://www.hpe.com/support.
• Power supply type 2x HPE 800W Flex Slot Titanium Hot Plug Low Halogen Power Supply Kit
• Memory type HPE DDR4 Smart Memory

Quickspecs

• QuickSpecs
• QuickSpecs (PDF)
• QuickSpecs
• QuickSpecs (HTML)

Overview

Do your servers need increased performance in storage, compute, or expansion? The HPE ProLiant DL380 Gen10 Plus server is adaptable for diverse workloads and environments, providing you with the right balance of expandability and scalability. Designed for supreme versatility and resiliency, this 2U/2P platform is capable for deployment in multiple environments, built on 3rd Generation Intel® Xeon® Scalable Processors, and backed by a comprehensive warranty. Equipped with PCIe Gen4 capabilities, the HPE ProLiant DL380 Gen10 Plus server offers improved data transfer rates and higher networking speeds.

What’s new

• Supports 3rd Generation Intel® Xeon® Scalable Processors.
• Support for PCIe Gen4, resulting in improved bandwidth and throughput.
• Support for industry-standard OCP 3.0 Network Adapters.
• Support for Trimodal (NVMe/SAS/SATA) HPE Smart Array controllers.

Features

360-degree Holistic Security

The HPE ProLiant DL380 Gen10 Plus server provides an enhanced, holistic, 360-degree view to security that begins in the manufacturing supply chain and concludes with a safeguarded, end-of-life decommissioning.

HPE ProLiant security begins with the corruption-free manufacture of the server and auditing the integrity of every component – hardware and firmware – to provide verification that the server begins its lifecycle uncompromised through the supply chain.

HPE ProLiant servers provide rapid detection of a security-compromised server, even to the point of not allowing it to boot, verify containment of malicious code, and protect healthy servers.

HPE ProLiant servers provide automated recovery from a security event, including restoration of validated firmware, and facilitating recovery of operating system, application and data connections, providing the fastest path to bring a server back online and into normal operations.

When it’s time to retire or repurpose an HPE ProLiant server, one button secure erase speeds and simplifies the complete removal of passwords, configuration settings and data, preventing inadvertent access to previously secured information.

Intelligent Management Automation

The HPE ProLiant DL380 Gen10 Plus server simplifies and automates management tasks, establishing a solid foundation for an open, hybrid cloud platform enabled by composability.

Embedded in HPE servers, HPE Integrated Lights-Out (iLO) is an exclusive core intelligence that monitors server status, providing the means for reporting, ongoing management, service alerting, and local or remote management to quickly identify and resolve issues.

Automation and software defined control reduces time spent on provisioning and maintenance, as well as reduces deployment times from weeks to mere days.

Available in an As-a-Service Experience

The HPE ProLiant DL380 Gen10 Plus server is supported by HPE GreenLake to simplify IT infrastructure management across your entire hybrid estate. With 24×7 monitoring and management, our experts do the heavy lifting to manage your environment with services built into consumption-based solutions.

Hewlett Packard Enterprise provides customers choice in how they acquire and consume IT beyond traditional financing and leasing, offering options that free trapped capital, accelerate infrastructure updates, and provide on-premises pay-per-use consumption with HPE GreenLake.

Built for Some of the Most Demanding Workloads

The HPE ProLiant DL380 Gen10 Plus server is built with foundational intelligence to transform IT with insights that enhance workload performance, placement, and efficiency, delivering better outcomes faster.

Provide real-time operational feedback on server performance and recommendations for fine-tuning BIOS settings to customize for changing business needs.

Media

HPE ProLiant DL380 Gen10 Plus Product Overview

HPE ProLiant servers deliver the intelligent compute foundation for the hybrid cloud delivering unmatched workload optimization, 360-degree security, and intelligent automation, all available with an as-a-Service experience.

Compatible products

• HPE 2.4TB SAS 12G Mission Critical 10K SFF BC 3-year Warranty 512e Multi Vendor HDD
• HPE 800W Flex Slot Platinum Hot Plug Low Halogen Power Supply Kit
• HPE 300GB SAS 12G Mission Critical 10K SFF BC 3-year Warranty Multi Vendor HDD
• Xilinx X2522-25G-PLUS Ethernet 10/25Gb 2-port SFP28 Adapter for HPE
• HPE DL38X Gen10 Plus x8/x16/x8 Secondary Riser Kit
• HPE MR416i-p Gen10 Plus x16 Lanes 4GB Cache NVMe/SAS 12G Controller
• HPE 1800W-2200W FS Ti Ht Plg PS Kit
• HPE 3.2TB NVME MU SFF BC U.3 PM1735A SSD
• HPE 3.2TB SAS 24G Mixed Use SFF BC Multi Vendor SSD
• HPE 8GB (1x8GB) Single Rank x8 DDR4-3200 CAS-22-22-22 Registered Smart Memory Kit
• HPE Smart Array P816i-a SR Gen10 (16 Internal Lanes/4GB Cache/SmartCache) 12G SAS Modular Controller
• Mellanox MCX512F-ACHT Ethernet 10/25Gb 2-port SFP28 Adapter for HPE
• HPE 6TB SATA 6G Business Critical 7.2K LFF LP 1-year Warranty 512e Multi Vendor HDD
• HPE 8TB SATA 6G Business Critical 7.2K LFF LP 1-year Warranty 512e Multi Vendor HDD
• HPE 16TB SAS 12G Business Critical 7.2K LFF LP 1-year Warranty Helium 512e ISE Multi Vendor HDD
• Marvell QL41132HQCU Ethernet 10Gb 2-port SFP+ OCP3 Adapter for HPE
• Broadcom BCM57504 Ethernet 10/25Gb 4-port SFP28 Adapter for HPE
• HPE SN1100Q 16Gb Dual Port Fibre Channel Host Bus Adapter
• HPE SN1610Q 32Gb 1-port Fibre Channel Host Bus Adapter
• HPE 7.68TB SATA RI SFF BC MV SSD
• HPE Bezel Lock Kit
• HPE 480GB SATA 6G Read Intensive SFF BC Multi Vendor SSD
• HPE ProLiant DL38x 8SFF SAS/SATA Tri-Mode Cable Kit
• HPE Smart Storage Hybrid Capacitor with 145mm Cable Kit
• HPE ProLiant DL38x Gen10 Plus 4LFF SAS/SATA Tri-Mode Cable Kit
• HPE Smart Array P408i-a SR Gen10 (8 Internal Lanes/2GB Cache) 12G SAS Modular Controller
• HPE NS204i-p x2 Lanes NVMe PCIe3 x8 OS Boot Device
• HPE DL380 SFF Smart Array HBA H200/P400 Series SAS Cable Kit
• HPE 480GB SATA 6G Mixed Use SFF BC Multi Vendor SSD
• HPE ProLiant DL380 Gen10 Plus High Performance Heat Sink Kit
• HPE 900GB SAS 12G Mission Critical 15K SFF BC 3-year Warranty Multi Vendor HDD
• HPE ProLiant DL36X Gen10 Plus High Performance Fan Kit
• HPE DL38X Gen10 Plus AROC to NVMe Adapter Kit
• HPE 16GB (1x16GB) Dual Rank x8 DDR4-3200 CAS-22-22-22 Registered Smart Memory Kit
• HPE C13 – C14 WW 250V 10Amp 2.0m Jumper Cord
• HPE SN1100Q 16Gb Single Port Fibre Channel Host Bus Adapter
• HPE DDR4 DIMM Blank Kit
• HPE 2TB SAS 12G Business Critical 7.2K LFF LP 1-year Warranty Multi Vendor HDD
• BCM 57414 10/25GbE 2p SFP28 Adptr
• HP OV 3yr 24×7 Supp Flex E-LTU
• HPE SN1200E 16Gb Dual Port Fibre Channel Host Bus Adapter
• HPE SN1610Q 32Gb 2-port Fibre Channel Host Bus Adapter
• HPE 3.84TB SATA 6G Read Intensive SFF BC Multi Vendor SSD
• HPE InfiniBand HDR100/Ethernet 100Gb 2-port QSFP56 PCIe4 x16 MCX653106A-ECAT Adapter
• HPE 1.92TB SATA 6G Mixed Use SFF BC Multi Vendor SSD
• Broadcom BCM5719 Ethernet 1Gb 4-port BASE-T Adapter for HPE
• HPE DL38X Gen10 Plus x8/x8 Tertiary Riser Kit
• HPE 96W Smart Storage Lithium-ion Battery with 145mm Cable Kit
• HPE SN1200E 16Gb Single Port Fibre Channel Host Bus Adapter
• HPE 1.92TB SATA 6G Read Intensive SFF BC Multi Vendor SSD
• HPE 800W Flex Slot -48VDC Hot Plug Low Halogen Power Supply Kit
• HPE 64GB 2Rx4 PC4-3200AA-R Smart Kit
• HPE Smart Array E208i-p SR Gen10 (8 Internal Lanes/No Cache) 12G SAS PCIe Plug-in Controller
• HPE 960GB SATA 6G Mixed Use SFF BC Multi Vendor SSD
• HPE Gen10 2U Bezel Kit
• HPE Trusted Platform Module 2.0 Gen10 Plus Black Rivets Kit
• HPE 600GB SAS 10K SFF BC MV HDD
• HPE 1.92TB NVMe RI SFF BC U.3 CM7 SSD
• HPE iLO Advanced Electronic License with 3yr Support on iLO Licensed Features
• HPE MR416i-a Gen10 Plus x16 Lanes 4GB Cache NVMe/SAS 12G Controller
• HPE Gen9 LFF HDD Spade Blank Kit
• HPE 12TB SATA 6G Business Critical 7.2K LFF LP 1-year Warranty Helium 512e Multi Vendor HDD
• HPE 1.8TB SAS 10K SFF BC 512E MV HDD
• HPE 5 Year Tech Care Basic DL380 Gen10/Gen10+ Smart Choice Service
• HPE 6TB SAS 12G Business Critical 7.2K LFF LP 1-year Warranty 512e Multi Vendor HDD
• Intel I350-T4 Ethernet 1Gb 4-port BASE-T Adapter for HPE
• HPE 20TB SATA 7.2K LFF LP ISE MV HDD
• HPE Proliant DL/ML Startup Service
• HPE Proliant DL/ML Install Service
• HPE 32GB (1x32GB) Dual Rank x4 DDR4-3200 CAS-22-22-22 Registered Smart Memory Kit
• HPE 9.5mm SATA DVD-RW Optical Drive
• HPE 1000W Flex Slot Titanium Hot Plug Power Supply Kit
• HPE Smart Array E208e-p SR Gen10 (8 External Lanes/No Cache) 12G SAS PCIe Plug-in Controller
• HPE 1600W Flex Slot Platinum Hot Plug Low Halogen Power Supply Kit
• HPE DL300 GEN10+ 2U 8SFF X1TMODE U.3 KIT
• Broadcom BCM5719 Ethernet 1Gb 4-port BASE-T OCP3 Adapter for HPE
• HPE 1.92TB NVMe Gen4 High Performance Read Intensive SFF BC U.3 PM1733a SSD
• MLX MCX631102 10/25GBE 2P SFP28 ADPTR
• HPE 800W Flex Slot Titanium Hot Plug Low Halogen Power Supply Kit
• HPE 4TB SAS 12G Business Critical 7.2K LFF LP 1-year Warranty Multi Vendor HDD
• HPE 960GB SATA 6G Read Intensive SFF BC Multi Vendor SSD
• HPE DL38X Gen10 Plus 2U SFF Easy Install Rail Kit
• HPE DL38X Gen10 Plus Maximum Performance Fan Kit
• HPE ProLiant DL380 Gen10 Plus Standard Heat Sink Kit
• Mellanox MCX562A-ACAI Ethernet 10/25Gb 2-port SFP28 OCP3 Adapter for HPE
• HPE 960GB SAS 12G Mixed Use SFF BC Value SAS Multi Vendor SSD
• HPE Smart Array P408i-p SR Gen10 (8 Internal Lanes/2GB Cache) 12G SAS PCIe Plug-in Controller
• HPE Small Form Factor Hard Drive Blank Kit
• HPE iLO Advanced 1-server License with 3yr Support on iLO Licensed Features
• HPE SN1610E 32GB 2P FC HBA
• HPE DL38X Gen10+ 2LFF Tertiary FIO Kit
• HPE 3 Year Tech Care Essential DL380 Gen10/Gen10+ Smart Choice Service
• HPE DL38X Gen10 Plus Primary NEBS-compliant Riser Kit
• HPE InfiniBand HDR100/Ethernet 100Gb 1-port QSFP56 PCIe4 x16 MCX653105A-ECAT Adapter
• HPE Mobile USB DVD-RW Optical Drive
• HPE 1.6TB NVMe Gen4 High Performance Mixed Use SFF BC U.3 PM1735a SSD
• HPE DL38X Gen10 Plus 2U Cable Management Arm for Rail Kit
• HPE DL38X Gen10 Plus 2U LFF Easy Install Rail Kit
• HPE iLO Advanced 1-server License with 1yr Support on iLO Licensed Features
• Broadcom BCM57416 Ethernet 10Gb 2-port BASE-T OCP3 Adapter for HPE
• Broadcom BCM57416 Ethernet 10Gb 2-port BASE-T Adapter for HPE
• HPE 16TB SATA 6G Business Critical 7.2K LFF LP 1-year Warranty Helium 512e ISE Multi Vendor HDD
• HPE Smart Array E208i-a SR Gen10 Ctrlr
• HPE Smart Array P408e-p SR Gen10 (8 External Lanes/4GB Cache) 12G SAS PCIe Plug-in Controller
• BCM 57412 10GBE 2P SFP+ OCP3 ADPTR
• Broadcom BCM57412 Ethernet 10Gb 2-port SFP+ Adapter for HPE
• HPE ProLiant DL38x LFF SAS/SATA Tri-Mode Cable Kit
• HPE 32GB microSD RAID 1 USB Boot Drive
• HPE OV for DL 3y 24×7 Bdl Track 1Svr Lic
• HPE DL38X Gen10 Plus x16/x16 Slot 1/2 Secondary Riser Kit
• HPE 240GB SATA 6G Read Intensive SFF BC Multi Vendor SSD
• HPE 3.84TB SAS RI SFF BC VS MV SSD
• Pensando Distributed Services Platform DSC-25 Enterprise 10/25Gb 2-port SFP28 Card
• HPE 960GB SATA 6G Read Intensive LFF LPC Multi Vendor SSD
• HPE iLO Advanced Electronic License with 1yr Support on iLO Licensed Features
• HPE ProLiant DL300 Gen10 Plus 2U Standard Fan Kit
• HPE 7.68TB SAS 12G Read Intensive SFF BC Value SAS Multi Vendor SSD
• Intel I350-T4 Ethernet 1Gb 4-port BASE-T OCP3 Adapter for HPE
• HPE 12TB SAS 12G Business Critical 7.2K LFF LP 1-year Warranty Helium 512e Multi Vendor HDD
• HPE 5 Year Tech Care Essential DL380 Gen10/Gen10+ Smart Choice Service
• HPE 1.2TB SAS 12G Mission Critical 10K SFF BC 3-year Warranty Multi Vendor HDD
• HPE InfiniBand HDR/Ethernet 200Gb 1-port QSFP56 PCIe4 x16 MCX653105A-HDAT Adapter
• HPE 3 Year Tech Care Basic DL380 Gen10/Gen10+ Smart Choice Service
• HPE DL38X Gen10 Plus x16 Tertiary Riser Kit
• HPE 9.5mm SATA DVD-ROM Jb Gen9 Kit

Documents

• Expanding patient services, reducing wait times – PrairieStar Health Center
• Iceotope Develops Innovative Cooling Systems for Extreme Environments
• Verified Reference Configuration – Intel-HPE VRC for NFVI and SASE
• HPE Reference Configuration for Red Hat OpenShift Virtualization on HPE ProLiant DL360 and DL380 Gen11 servers using Red Hat OpenShift Container Platform 4.15
• HPE Firmware and Software Compatibility Matrix for VMware Cloud Foundation 4.3.1 on HPE Synergy and HPE ProLiant Servers Dec2021
• 360-Degree Security where and when you need it
• Azure Stack HCI – Secured-Core Server solution overview
• HPE ProLiant DL360 Gen10 Plus and HPE ProLiant DL380 Gen10 Plus Servers Building Blocks for SAP Implementation
• Expanding patient services, reducing wait times – PrairieStar Health Center
• Upgrading VMware Cloud Foundation from 4.0.1 to 4.2.1 on HPE Servers
• HPE and Bloombase – HPE ProLiant and Bloombase StoreSafe Intelligent Storage Firewall
• How To Choose The Right AI Tools To Create Value
• HPE ProLiant DL380 Gen10 Plus – Carrier Grade Supplement QuickSpecs
• HPE ProLiant DL380 Gen10 Plus Server QuickSpecs
• HPE and F5 – HPE ProLiant and F5 BIG-IP ADC and F5 Distributed Cloud Platform
• HPE Server Performance Benchmarks Newsletter
• Next-Gen Data Backup Drives Secure, Scalable, Manageable IT
• HPE ProLiant Compute DL380a Gen12
• Expanding patient services, reducing wait times – PrairieStar Health Center